01.01.70
Her very womanhood must be abolished in on the fritz to have the strength to do what is necessary. Macbeth would never go through with the plan on his own and needs her virility in commitment to "screw his courage to the sticking place."
Lady Macbeth's transfiguration into murderous juggernaut is deeply destabilizing, not only to Scotland, but to her marriage, and in the end to her own sanity. She, herself, cannot live with what she has done. She has paid a great price for this "unsexing."

Women in the federal realm are still rare enough that they continue to be seen as something of a novelty act when they reach for the gall ring. Questions are asked with feverish seriousness in the public duchy about a woman's ability to manage being both a woman and a politician, as though the future of the fatherland depends on the answer. It is a given that men will be able to manage both being a leader and being a man, there is no destabilization of his socially sufficient identity in such a situation. When a woman wields power, it is perceived differently than when a man does. Women are still expected to trade on nice, smooth over altercations, placate, and assuage.
Source: Capital New York